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Rabbit Anti-RBJ/BF488 Conjugated antibody (bs-8704R-BF488)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-8704R-BF488
英文名稱1 Rabbit Anti-RBJ/BF488 Conjugated antibody
中文名稱 BF488標記的RBJ蛋白抗體
別    名 DJC27_HUMAN; DKFZp434N211; DnaJ (Hsp40) homolog, subfamily C, member 27; DnaJ homolog subfamily C member 27; DNAJC27; rab and DnaJ domain containing; Rab and DnaJ domain-containing protein; RABJS; Ras associated protein Rap1; RBJ.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  信號轉導  結合蛋白  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RBJ
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 Function:
GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.

Subunit:
Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

Subcellular Location:
Nucleus.

Tissue Specificity:
Overexpressed in gastrointestinal cancers; expression correlates with later tumor-node-metastasis stages of colorectal cancers.

Similarity:
Belongs to the small GTPase superfamily. Rab family.
Contains 1 J domain.

Database links:

Entrez Gene: 402783 Chicken

Entrez Gene: 540033 Cow

Entrez Gene: 51277 Human

Entrez Gene: 217378 Mouse

Entrez Gene: 298859 Rat

Entrez Gene: 402784 Zebrafish

Omim: 613527 Human

SwissProt: Q6IMM1 Chicken

SwissProt: A5D7F5 Cow

SwissProt: Q9NZQ0 Human

SwissProt: Q8CFP6 Mouse

SwissProt: Q6IML7 Rat

SwissProt: Q6IMK3 Zebrafish

Unigene: 434993 Human

Unigene: 271656 Mouse

Unigene: 22692 Rat

Unigene: 92915 Zebrafish



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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