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Rabbit Anti-PTPD2/Cy5.5 Conjugated antibody (bs-8692R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@www.chomd.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@www.chomd.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-8692R-Cy5.5
英文名稱1 Rabbit Anti-PTPD2/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的細胞骨架相關蛋白酪氨酸磷酸酶2抗體
別    名 Cytoskeletal associated protein tyrosine phosphatase; MGC126803; PEZ; Phosphatase with ezrin domain; Protein tyrosine phosphatase non receptor type 14; Protein tyrosine phosphatase pez; Protein-tyrosine phosphatase pez; PTN14_HUMAN; PTP 36; PTP36; PTPD 2; PTPN 14; PTPN14; Tyrosine protein phosphatase non receptor type 14; Tyrosine-protein phosphatase non-receptor type 14.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  激酶和磷酸酶  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 135kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTPD2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]

Function:
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis.

Subcellular Location:
Cytoplasm > cytoskeleton.

Tissue Specificity:
Expressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

DISEASE:
Defects in PTPN14 are a cause of choanal atresia and lymphedema (CHATLY) [MIM:613611]. A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. Note=A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family.

Similarity:
Belongs to the protein-tyrosine phosphatase family.
Non-receptor class subfamily.
Contains 1 FERM domain.
Contains 1 tyrosine-protein phosphatase domain.

Database links:

Entrez Gene: 5784 Human

Omim: 603155 Human

SwissProt: Q15678 Human

Unigene: 193557 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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