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Rabbit Anti-RGS12/Cy5.5 Conjugated antibody (bs-19853R-Cy5.5)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-19853R-Cy5.5
英文名稱1 Rabbit Anti-RGS12/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的G蛋白信號轉導調節因子12抗體
別    名 DKFZp761K1617; Regulator of G protein signalling 12.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  表觀遺傳學  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 156kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RGS12
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.

Subunit:
Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent.

Subcellular Location:
Nuclear

Tissue Specificity:
Isoform 3 is brain specific.

Similarity:
Contains 1 GoLoco domain.
Contains 1 PDZ (DHR) domain.
Contains 1 PID domain.
Contains 2 RBD (Ras-binding) domains.
Contains 1 RGS domain.


Database links:

Entrez Gene: 6002 Human

Entrez Gene: 71729 Mouse

Entrez Gene: 54292 Rat

Omim: 602512 Human

SwissProt: O14924 Human

SwissProt: Q8CGE9 Mouse

SwissProt: O08774 Rat

Unigene: 196208 Mouse

Unigene: 9796 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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