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Rabbit Anti-Granuphilin/SYTL4/PE-Cy7 Conjugated antibody (bs-16310R-PE-Cy7)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-16310R-PE-Cy7
英文名稱 Rabbit Anti-Granuphilin/SYTL4/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標記的突觸結合蛋白樣蛋白4抗體
別    名 DKFZp451P0116; Exophilin-2; FLJ40960; Granuphilin; SLP4; Synaptotagmin like 4; Synaptotagmin-like protein 4; Sytl4; SYTL4_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  信號轉導  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Dog, Cow, Horse, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 76kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Granuphilin/SYTL4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]

Function:
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner.

Subunit:
Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B. Interacts with MYO5A (By similarity).

Subcellular Location:
Membrane. Cell membrane. Cytoplasmic vesicle > secretory vesicle membrane. Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles.

Similarity:
Contains 2 C2 domains.
Contains 1 FYVE-type zinc finger.
Contains 1 RabBD (Rab-binding) domain.

Database links:

Entrez Gene: 94121 Human

Entrez Gene: 27359 Mouse

Entrez Gene: 140594 Rat

Omim: 300723 Human

SwissProt: Q96C24 Human

SwissProt: Q9R0Q1 Mouse

SwissProt: Q8VHQ7 Rat

Unigene: 592224 Human

Unigene: 38674 Mouse

Unigene: 107417 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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