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Rabbit Anti-TET1/FITC Conjugated antibody (bs-8523R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@www.chomd.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@www.chomd.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-8523R-FITC
英文名稱 Rabbit Anti-TET1/FITC Conjugated antibody
中文名稱 FITC標記的Ten-eleven轉運基因1蛋白抗體
別    名 Leukemia associated protein with a CXXC domain; CXXC 6; CXXC finger 6; CXXC type zinc finger protein 6; CXXC-type zinc finger protein 6; CXXC6; KIAA1676; LCX; Leukemia-associated protein with a CXXC domain; Methylcytosine dioxygenase TET1; Ten eleven translocation 1 gene protein; Ten eleven translocation 1 gene protein homolog; Ten-eleven translocation 1 gene protein; Tet 1; Tet oncogene 1; TET1; TET1_HUMAN; TET1/CXXC6.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  干細胞  轉錄調節因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 235kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TET1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
TET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,136 amino acid protein that localizes to the nucleus and contains one CXXC-type zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Subunit:
Interacts with SIN3A; recruits the transcriptional co-repressor SIN3A to gene promoters.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in fetal heart, lung and brain, and in adult skeletal muscle, thymus and ovary.

Similarity:
Belongs to the TET family.
Contains 1 CXXC-type zinc finger.

Database links:

Entrez Gene: 80312 Human

Entrez Gene: 52463 Mouse

Entrez Gene: 309902 Rat

Omim: 607790 Human

SwissProt: Q8NFU7 Human

SwissProt: Q3URK3 Mouse

Unigene: 567594 Human

Unigene: 708977 Human

Unigene: 17774 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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