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Rabbit Anti-Cyclin B3/BF488 Conjugated antibody (bs-7884R-BF488)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7884R-BF488
英文名稱 Rabbit Anti-Cyclin B3/BF488 Conjugated antibody
中文名稱 BF488標記的周期素B3抗體
別    名 CCNB 3; CCNB3; CYCB3; G2/mitotic specific cyclin B3.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  染色質和核信號  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 158kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin B3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene belongs to the highlyconserved cyclin family, whose members are characterized by adramatic periodicity in protein abundance through the cell cycle.Cyclins function as positive regulators of cyclin-dependent kinases(CDKs), and thereby play an essential role in the control of thecell cycle. Different cyclins exhibit distinct expression anddegradation patterns, which contribute to the temporal coordinationof each mitotic event. Studies of similar genes in chicken anddrosophila suggest that this cyclin may associate with CDC2 andCDK2 kinases, and may be required for proper spindle reorganizationand restoration of the interphase nucleus. Alternatively splicedtranscript variants encoding different isoforms have been describedfor this gene.

Function:
Cyclins are positive regulatory subunits of thecyclin-dependent kinases (CDKs), and thereby play an essential rolein the control of the cell cycle, notably via their destructionduring cell division. Its tissue specificity suggest that it may berequired during early meiotic prophase I.

Subunit:
Interacts with CDK2 kinase.

Subcellular Location:
Nucleus.

Tissue Specificity:
Testis specific. In testis, it is expressed indeveloping germ cells, but not in Leydig cells. Weakly or notexpressed in other tissues.

Post-translational modifications:
Ubiquitinated (Probable). Ubiquitination leads to itsdegradation during anaphase entry, after degradation of CCNB1.

Similarity:
Belongs to the cyclin family. Cyclin AB subfamily.

Database links:
UniProtKB/Swiss-Prot: Q8WWL7.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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