| 產(chǎn)品編號 | bs-0571R-APC |
| 英文名稱 | Rabbit Anti-Cyclin A2/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的周期素A2抗體 |
| 別 名 | CCN1; CCNA; CCNA2; Cyclin A2; CCNA2_HUMAN; Cyclin-A2; CCNA2; Cyclin-A. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 細(xì)胞周期蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Cyclin A |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]. Function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. Subunit: Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER. Subcellular Location: Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER. Post-translational modifications: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity). Similarity: Belongs to the cyclin family. Cyclin AB subfamily. Database links: Entrez Gene: 890 Human Entrez Gene: 12428 Mouse Omim: 123835 Human SwissProt: P20248 Human SwissProt: P51943 Mouse Unigene: 58974 Human Unigene: 4189 Mouse Unigene: 13094 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Cyclin A 可以出現(xiàn)在所有類型的細(xì)胞。各周期素可出現(xiàn)在不同的細(xì)胞增殖周期中。能結(jié)合和激活CDK2激酶，促進(jìn)細(xì)胞G1/S和G2/M增殖周期的轉(zhuǎn)化。 |
