亚洲中文字幕特级毛片-亚洲制服丝袜中文字幕-亚洲制服丝袜在线观看-亚洲制服欧美自拍另类-免费一级黄色-免费一级国产生活片

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
波多野结衣av无码久久一区,国产chinese中国hdxxxx,免费在线观看视频a
Rabbit Anti-Phospho-IRF3 (Ser396)/Cy5 Conjugated antibody (bs-3195R-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@www.chomd.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@www.chomd.com.cn
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3195R-Cy5
英文名稱1 Rabbit Anti-Phospho-IRF3 (Ser396)/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的磷酸化干擾素調(diào)節(jié)因子3
別    名 IRF3 (phospho S396); IRF3 (phospho Ser396); p-IRF3 (Ser396); p-IRF3 (S396); Interferon regulatory factor 3; IRF 3; IRF-3; IRF3; IRF3_HUMAN; MGC94729.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human IRF3 around the phosphorylation site of Ser396
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].

Function:
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

Subunit:
Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF7. Interacts with CREBBP. May interact with MAVS. Interacts with IKBKE and TBK1. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1 (via C-terminus); this interaction leads to the proteasome-dependent degradation of IRF3. Interacts with RBCK1. Interacts with TRIM21. Interacts with HERC5.

Subcellular Location:
Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.

Tissue Specificity:
Expressed constitutively in a variety of tissues.

Post-translational modifications:
Constitutively phosphorylated on many serines residues. C-terminal serine/threonine cluster is phosphorylated in response of induction by IKBKE and TBK1. Ser-385 and Ser-386 may be specifically phosphorylated in response to induction. An alternate model propose that the five serine/threonine residues between 396 and 405 are phosphorylated in response to a viral infection. Phosphorylation, and subsequent activation of IRF3 is inhibited by vaccinia virus protein E3.
Ubiquitinated; ubiquitination involves RBCK1 leading to proteasomal degradation. Polyubiquitinated; ubiquitination involves TRIM21 leading to proteasomal degradation.
ISGylated by HERC5 resulting in sustained IRF3 activation and in the inhibition of IRF3 ubiquitination by disrupting PIN1 binding. The phosphorylation state of IRF3 does not alter ISGylation.

Similarity:
Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

Database links:

Entrez Gene: 3661 Human

Entrez Gene: 54131 Mouse

Omim: 603734 Human

SwissProt: Q14653 Human

SwissProt: P70671 Mouse

Unigene: 289052 Human

Unigene: 75254 Human

Unigene: 3960 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

干擾素調(diào)節(jié)因子家族是一大類對(duì)干擾素起調(diào)控作用的轉(zhuǎn)錄因子的統(tǒng)稱。 一般認(rèn)為干擾素調(diào)節(jié)因子(IRF)通過(guò)調(diào)節(jié)干擾素的表達(dá)而行使其抗病毒、應(yīng)激、免疫調(diào)節(jié)功能。近年來(lái),研究人員發(fā)現(xiàn)IRF在細(xì)胞凋亡、細(xì)胞周期、細(xì)胞分化、腫瘤發(fā)生中也起著重要的調(diào)節(jié)作用。
版權(quán)所有 2004-2026 www.www.chomd.com.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 一本无码在线无码AV无码| 熟妇人妻无码中文字幕母孑| 国内精品伊人久久久影院_第1集| 国内精品卡1卡2卡区别电影| 99久久精品国产麻豆free| 亚洲精品久久久久中文字幕69| 美女在线视频黄色抹胸直播| 高潮喷水AV一区二区同人漫画| 亚洲五月六月丁香激情11月| 免费一区二区无码视频在线播放网站| 国语自产精品视频在线看 抢先版图片 | 少妇被黑人到高潮喷出白浆| 精品人妻人人做人人爽夜夜爽,久久午夜无 | 无码中文字幕日韩专区下载蜜臀| 久久国产精彩视频368| 竹菊精品久久久久久久9电影| 五月份视频在线播放| 国产伊人无码秒拍福利| 亚洲一欧洲中文字幕在线电影| 就要操就要操就要操就要操就要 | 亚洲精品高湖牙蜜区久久久久久 | 久久精品国产亚洲网站 - V999AV| 苍老师高潮国产免费| 无码午夜福利片透明人系列| 国产精品地址免费一呦二呦三呦| 国产三级在线观看播放视频色精屋| 制服丝袜在线亚洲导航| 久久精品中文字幕一区二区三区公司| eeuss天堂影院手机在线| 日本动漫资源免费观看| 中文字幕一区二区视频一区二区亚洲| 人妻japanesefree人妻| 中文字幕视频不卡一区在线 | 天堂8在线天堂资源b+t | 国产激情无码一区二区app-极品人动作 | 无码人妻少妇色欲AV一区二区| 丁香五月网久久综合网,狠色伊人亚洲| 羞羞爽爽男女午夜影视浪潮av | 精品无码国产污污污免费网站应用无遮挡| 玉足白丝口爆吞精在线观看| 精品aⅴ无码中文字字幕蜜桃91|