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Rabbit Anti-VE Cadherin/PE-Cy7 Conjugated antibody (bs-4310R-PE-Cy7)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-4310R-PE-Cy7
英文名稱1 Rabbit Anti-VE Cadherin/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的上皮型鈣粘附分子抗體
別    名 VE-cadherin; cadherin-5; VE-Cadherin;Cdh5; Vascular endothelial cadherin; 7B4 antigen; CD144 antigen; VECD; Vascular endothelial cell cadherin; 7B 4; 7B4; 7B4 antigen; Cadherin 5; Cadherin 5 type 2; Cadherin-5; Cadherin5; CD 144; CD144; CD144 antigen; CDH 5; CDH5; CDH5 protein; Vascular endothelial cadherin; Vascular epithelium cadherin; VE Cad antibody VE-cadherin; VE cadherin; VEC; CADH5_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  細(xì)胞粘附分子  血管內(nèi)皮細(xì)胞  內(nèi)皮細(xì)胞  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 81kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VE Cadherin (251-320aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008].

Function:
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.

Subunit:
Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1.

Subcellular Location:
Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries.

Tissue Specificity:
Endothelial tissues and brain.

Post-translational modifications:
Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB.

Similarity:
Contains 5 cadherin domains.

Database links:

Entrez Gene: 1003 Human

Entrez Gene: 12562 Mouse

Entrez Gene: 307618 Rat

Omim: 601120 Human

SwissProt: P33151 Human

SwissProt: P55284 Mouse

Unigene: 76206 Human

Unigene: 21767 Mouse

Unigene: 224644 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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