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Rabbit Anti-Antithrombin III /SERPINC1/Gold Conjugated antibody (bs-1636R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-1636R-Gold
英文名稱1 Rabbit Anti-Antithrombin III /SERPINC1/Gold Conjugated antibody
中文名稱 膠體金標記的抗凝血酶3抗體
別    名 AntithrombinIII; Antithrombin III; AT 3; AT III; AT3; ATIII; MGC22579; Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1; Serine Proteinase Inhibitor Clade C Member 1; SERPIN C1; Serpin peptidase inhibitor clade C (antithrombin) member 1; SERPINC1; ATH III.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 心血管  細胞生物  免疫學  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, Pig, Cow, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Antithrombin III
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009].

Function:
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Subunit:
Forms protease inhibiting heterodimer with TMPRSS7.

Subcellular Location:
Secreted, extracellular space.

Tissue Specificity:
Plasma.

Post-translational modifications:
Phosphorylation sites are present in the extracellular medium.

Similarity:
Belongs to the serpin family.

Database links:

Entrez Gene: 462 Human

Entrez Gene: 11905 Mouse

Entrez Gene: 304917 Rat

Omim: 107300 Human

SwissProt: P01008 Human

SwissProt: P32261 Mouse

Unigene: 75599 Human

Unigene: 260770 Mouse

Unigene: 204806 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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