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Rabbit Anti-ARC/AP Conjugated antibody (bs-0385R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0385R-AP
英文名稱 Rabbit Anti-ARC/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的即刻早期基因ARC抗體
別    名 ARG3.1; Arc; Arg 3.1; Activity regulated cytoskeletal associated protein; Activity regulated cytoskeletal protein; Activity-regulated cytoskeleton-associated protein; Activity regulated cytoskeletal-associated protein; ARC/ARG3.1; Activity-regulated gene 3.1 protein homolog; Activity regulated gene 3.1 protein homolog; Arg3.1; KIAA0278; ARC_HUMAN; growth factor ARC.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Cow, Horse, Rabbit, )
產品應用 WB=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ARC
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Activity-regulated cytoskeleton-associated protein (ARC)in the brain and learning and memory, researchers believe: ARC protein is by strengthening the function of synaptic links in order to save the memory, including learning and memory and emotion. At present, the scientists will also Activity-regulated cytoskeleton-associated protein used to take drugs addiction.

Function:
Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.

Subunit:
Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2.

Subcellular Location:
Cytoplasm, cytoskeleton. Endosome. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse.

Similarity:
Belongs to the ARC/ARG3.1 family.

Database links:

Entrez Gene: 23237 Human

Entrez Gene: 11838 Mouse

Entrez Gene: 54323 Rat

Omim: 605235 Human

SwissProt: Q7LC44 Human

SwissProt: Q9WV31 Mouse

SwissProt: Q63053 Rat

Unigene: 40888 Human

Unigene: 741621 Human

Unigene: 25405 Mouse

Unigene: 10086 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

該蛋白與大腦的學習記憶有關,研究人員認為:是ARC蛋白通過加強了突觸的聯系功能從而儲存了這些記憶,包括情感和學習記憶。
目前,科學家也將該蛋白用于吸食毒品成癮性的研究。
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