亚洲中文字幕特级毛片-亚洲制服丝袜中文字幕-亚洲制服丝袜在线观看-亚洲制服欧美自拍另类-免费一级黄色-免费一级国产生活片

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
亚洲欧美一区二区三区,日本牲交大片无遮挡,99久久亚洲精品无码毛片
Rabbit Anti-GNAT3/BF350 Conjugated antibody (bs-6149R-BF350)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@www.chomd.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@www.chomd.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6149R-BF350
英文名稱1 Rabbit Anti-GNAT3/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的G蛋白轉(zhuǎn)錄因子α3抗體
別    名 GDCA; Ggust; Gnat 3; GNAT3; GNAT3_HUMAN; Gtn; Guanine nucleotide binding protein alpha transducing 3; Guanine nucleotide binding protein G(t) subunit alpha 3; Guanine nucleotide-binding protein G(t) subunit alpha-3; Gustducin alpha 3; Gustducin alpha 3 chain.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞周期蛋白  通道蛋白  G蛋白信號(hào)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 40kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GNAT3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (e.g., adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein alpha, beta and gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their alpha subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of Ga subunits have been identified; these include Gs, Gi, Gq and Ga 12/13. Gustducin has been identified as a taste-cell-specific G protein within the Gi subclass of Ga subunit proteins that is most closely related to the transducins and exclusively expressed in taste buds.

Function:
Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.

Subunit:
G proteins are composed of 3 units; alpha, beta and gamma, respectively GNAT3, GNB1 and GNG13 for Gustducin heterotrimer for bitter taste transduction. The alpha chain contains the guanine nucleotide binding site. Gustducin heterotrimer may also be composed of GNAT3, GNB3 and GNG13.

Subcellular Location:
Cytoplasm. Dual ditribution pattern; plasmalemmal pattern with apical region localization and cytosolic pattern with localization throughout the cytoplasm.

Tissue Specificity:
Expressed in taste buds (sensory organs of clustered epithelial cells) of the circumvallate and foliate papillae of the tongue at protein level. Expressed in enteroendocrine L cells of the gut. Detected also in spermatozoa.

Post-translational modifications:
Potential N-myristoylation may anchor alpha-subunit to the inner surface of plasma membrane.

Similarity:
Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Database links:

Entrez Gene: 346562 Human

Entrez Gene: 242851 Mouse

Entrez Gene: 286924 Rat

Omim: 139395 Human

SwissProt: A8MTJ3 Human

SwissProt: Q3V3I2 Mouse

SwissProt: P29348 Rat

Unigene: 335049 Human

Unigene: 332230 Mouse

Unigene: 10456 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.www.chomd.com.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 国精产品一区一区三区mba下载蜜臀 | 日韩人妻无码精品专区99| 无码成人精品区在线观看_在线观看国产免 | 最清晰的女厕偷拍77777视频| 亚洲小说区图片区另类春色综| 色噜噜中文字幕av导航| 国产男男在线污污| 亚洲熟妇AV乱码在线观看嫂子| 久久久久亚洲AV无码专区永久| x7x7x7任意噪108| 天天操天天干天天做天天插大香蕉| 激情综合婷婷丁香五月可下载| 中文字幕乱码第一页制服诱惑| 欧美另类熟妇与子伦HD| 91在线无码精品秘?入口网站| 色哟哟亚洲精品少妇| 成人精品视频一区二区三区下载 | 人妻人人爽人人澡人人妻| 东北老妇露脸无码蜜芽| 香蕉成人伊视频在线观看网址白皙白皙 | 国内精品卡1卡2卡区别在哪| 一级做a爱片特黄在线观看放学多后| 久久久无码日本伦一本二本理电影| 中文字幕在线视频不卡| 久久久久综合国产免费乐播| 中国老人真实写照,看完泪奔!| 久久精品黄AA片一区二区三区嫂子 | 久久久中文av| 夜爽8888视频在线观看| 黑色超薄丝袜脚交爽91| 亚洲AV无码乱码棈品国产五十路| 国产乱子伦精品视频,国产乱| 无码国内精品人妻少妇a?v | 精品国产一区二区三区免费_日| 亚洲视屏在线观看永久观看 | 一级做a爰片久久免费观看直播 | 草莓视频在线观看官方入口18禁| 日韩精品一区二区三区中文字幕在线观看中文字幕 | 久久伊精品无码二区| 一区 二区 三区 中文字幕 无码 | 亚洲精品美女在线观看播放 |