亚洲中文字幕特级毛片-亚洲制服丝袜中文字幕-亚洲制服丝袜在线观看-亚洲制服欧美自拍另类-免费一级黄色-免费一级国产生活片

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
内射毛片内射国产夫妻,免费又黄又爽1000禁片,中文字幕av无码不卡免费
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-RbAp48/BF555 Conjugated antibody (bs-6130R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@www.chomd.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@www.chomd.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6130R-BF555
英文名稱 Rabbit Anti-RbAp48/BF555 Conjugated antibody
中文名稱 BF555標記的視網膜母細胞瘤結合蛋白P48抗體
別    名 RBBP4_HUMAN; Histone-binding protein RBBP4; Chromatin assembly factor 1 subunit C; CAF-1 subunit C; Chromatin assembly factor I p48 subunit; CAF-I 48 kDa subunit; CAF-I p48; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; RBBP-4; Retinoblastoma-binding protein p48.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Rabbit, Zebrafish, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RbAp48
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
RbAp48 (Retinoblastoma-binding protein p48 or Rb-associated protein p48)is a WD repeat protein that is a core histone binding subunit common to several complexes involved in chromatin assembly, chromatin remodeling, and histone deacetylation. These complexes include Chromatin Assembly Factor 1 (CAF1), which is required for chromatin assembly following DNA replication and repair, the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and subsequent transcriptional repression, the nucleosome remodeling and histone deacetylation complex NuRD, the nucleosome remodeling factor (NURF) complex, and the PRC2 complex, which promotes repression of homeotic genes during development. RpAp48 also interacts with the retinoblastoma protein, and with SPEN/MINT and BRCA1. It is also a component of the DREAM complex, which represses cell cycle-dependent genes in quiescent cells.

Function:
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Subunit:
Interacts with SUV39H1 and HDAC7 (By similarity). Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the chromatin assembly factor 1 (CAF-1) complex, which is composed of RBBP4, CHAF1B and CHAF1A. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1). Interacts with SPEN/MINT. Interacts with BRCA1. Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
Contains 6 WD repeats.

Database links:

Entrez Gene: 395658 Chicken

Entrez Gene: 767940 Cow

Entrez Gene: 5928 Human

Entrez Gene: 19646 Mouse

Entrez Gene: 313048 Rat

Entrez Gene: 496866 Xenopus tropicalis

Entrez Gene: 321726 Zebrafish

Omim: 602923 Human

SwissProt: Q9W7I5 Chicken

SwissProt: Q3MHL3 Cow

SwissProt: Q09028 Human

SwissProt: Q60972 Mouse

SwissProt: Q5RF92 Orangutan

SwissProt: Q5M7K4 Xenopus tropicalis

SwissProt: Q6P3H7 Zebrafish

Unigene: 16003 Human

Unigene: 12145 Mouse

Unigene: 76462 Zebrafish



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.www.chomd.com.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产精品久久久久久妇女6080| 亚洲一区二区毛片机智观看| 懂色av蜜臀av粉嫩av分享吧在线观看 | 黑色超薄丝袜脚交爽91| 三上悠亚中文在线观看字幕| 西西人体444高清美女图片| 无码粉嫩小泬无套在线观看软件视频 | 午夜不卡久久精品无码免费17c| 亚洲成AV人片在线观看无兔子先生 | 欧洲成人午夜精品无码区久久出生证明是啥颜色本子 | 久久久久久久精品成人热色戒金瓶梅 | 熟女精品视频一区二区三区喷白桨| 亚洲综合国产一区二区三区红桃 | 国产成人无码精品久久久免费-精品国产乱码久久久久久 | 中文字幕无码少妇HD| 伊人精品综合午| 亚洲欧洲在线播放18| 亚洲精品高清国产久久久久久| 亚洲网红精品大秀在线观看| 老鬼色无码精品一二三区| 久久精品一区二区三区不卡牛牛丰满女人视频 | 国产精品高潮???69| 亚洲国产婷婷综合在线精品中文| 久久这里只有精品国产13| 久久国产护士视频| 国产护士在线情| 亚洲国产欧洲综合997久久_边做饭边被躁b | 午夜天堂一区人妻美女永久免费 | 一级做a爰片久久毛片1女多男视频 | 精品久久久久中文字幕人妻蜜臀97资源 | 岛国无码在线播放蜜臀hd| 国偷精品无码久久久久蜜桃软件| 91精品国产综合久久精品,亚洲精品国产专区9 | 三上悠亚日韩在线一区观看| windowschannel孕妇生产 | 中文字幕A片| 婷婷五月深深久久精品|网站| 国产在线AAA片一区二区91| a级成人毛片久久软件下载 | 无码福利一区二区三区视频免费无码不卡| 久久精品国产乱子伦多人,性亚洲精品 |