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Laminin alpha 1 Rabbit pAb (bs-41199R)  
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產品編號 bs-41199R
英文名稱 Laminin alpha 1 Rabbit pAb
中文名稱 層粘蛋白α1抗體
別    名 LAMA; LAMA1; Laminin A chain; Laminin subunit alpha-1; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha; Laminin subunit alpha-1; LAMA1_HUMAN; Laminin-1 subunit alpha; Laminin-3 subunit alpha.  Laminin α-1; Laminin α1; Laminin α 1; Laminin subunit α1; Laminin subunit α-1.
研究領域 細胞生物  神經生物學  信號轉導  細胞粘附分子  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 337 kDa
檢測分子量
細胞定位 細胞膜 細胞外基質 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Laminin alpha 1: N-terminal 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014].

Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Subunit:
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin).

Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Similarity:
Contains 17 laminin EGF-like domains.
Contains 5 laminin G-like domains.
Contains 2 laminin IV type A domains.
Contains 1 laminin N-terminal domain.

SWISS:
Q9Y6N6

Gene ID:
3918

Database links:

Entrez Gene: 284217 Human

Entrez Gene: 16772 Mouse

Entrez Gene: 316758 Rat

Omim: 150320 Human

SwissProt: P25391 Human

SwissProt: P19137 Mouse

SwissProt: Q9R0B6 Mouse

Unigene: 201805 Human

Unigene: 270364 Human

Unigene: 302362 Mouse



產品圖片
Sample: Lane 1: Recombinant human Laminin Alpha-1 protein Primary: Anti-Laminin alpha 1 (bs-41199R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 337 kDa Observed band size: 26 kDa
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