| 產品編號 | bs-18568R |
| 英文名稱 | Rabbit Anti-ZSWIM7 antibody |
| 中文名稱 | ZSWIM7蛋白抗體 |
| 別 名 | SWIM domain-containing and Srs2-interacting protein 1 homolog; SWIM domain-containing Srs2-interacting protein 1; SWIM-type zinc finger domain-containing protein 7; SWS1; Zinc finger SWIM domain-containing protein 7; Zinc finger, SWIM-type containing 7; zswim7; ZSWM7_HUMAN. |
| 研究領域 | 細胞生物 鋅指蛋白 表觀遺傳學 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | (predicted: Human,Mouse,Rat,Sheep,Cow,Dog,Horse) |
| 產品應用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 15kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZSWIM7: 21-120/140 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產品介紹 |
ZSWIM7 is a 140 amino acid nuclear protein that contains a SWIM-type zinc finger and belongs to the SWS1 family. ZSWIM7 interacts with Rad51D, and plays a role in the early stages of the homologous recombination repair (HRR) pathway that occurs during double-stranded DNA breaks. The gene encoding ZSWIM7 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Function: Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Subcellular Location: Nucleus. Similarity: Belongs to the SWS1 family. Contains 1 SWIM-type zinc finger. SWISS: Q19AV6 Gene ID: 125150 Database links: Entrez Gene: 125150 Human Omim: 614535 Human SwissProt: Q19AV6 Human Unigene: 593985 Human |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
