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Rabbit Anti-MMRN2  antibody (bs-17688R)  
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產品編號 bs-17688R
英文名稱 Rabbit Anti-MMRN2  antibody
中文名稱 細胞外基質糖蛋白MMRN2抗體
別    名 Elastin microfibril interface located protein 3; Elastin microfibril interfacer 3; EMILIN-3; EndoGlyx-1 p125/p140 subunit; MMRN2; MMRN2_HUMAN; Multimerin-2.  
研究領域 腫瘤  細胞生物  信號轉導  糖蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat (predicted: Human,Mouse,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 104kDa
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMRN2: 361-460/949 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]

Function:
Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.

Subunit:
Heteromer of p110, p125, p140 and p200 subunits;disulfide-linked. Interacts with VEGFA.

Subcellular Location:
Secreted > extracellular space > extracellular matrix.

Tissue Specificity:
Endothelium.

Post-translational modifications:
N- and O-glycosylated.

Similarity:
Contains 1 C1q domain.
Contains 1 EMI domain.

SWISS:
Q9H8L6

Gene ID:
79812

Database links:

Entrez Gene: 79812 Human

Omim: 608925 Human

SwissProt: Q9H8L6 Human

Unigene: 524479 Human



產品圖片
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MMRN2) Polyclonal Antibody, Unconjugated (bs-17688R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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