| 產(chǎn)品編號 | bs-16525R |
| 英文名稱 | Rabbit Anti-ZNF675 antibody |
| 中文名稱 | 鋅指蛋白675抗體 |
| 別 名 | FLJ36350; TBZF; TIZ; TRAF6-binding zinc finger protein; TRAF6-inhibitory zinc finger protein; Zinc finger protein 675; ZN675_HUMAN; ZNF 675; ZNF675. |
| 研究領(lǐng)域 | 轉(zhuǎn)錄調(diào)節(jié)因子 鋅指蛋白 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 66kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZNF675: 201-300/568 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. TBZF (TRAF6-inhibitory zinc finger protein), also known as Zinc finger protein 675, is a 568 amino acid nuclear protein that contains one KRAB domain and fifteen C2H2-type zinc fingers. Through modulation of TRAF6 signaling activity and inhibition of RANK signaling, TBZF may play a role in osteoclast differentiation. TBZF is regulated during differentiation of human peripheral blood monocytes into osteoclasts and transfection of TBZF into RAW264.7 cells reduces RANK ligand-induced osteoclastogenesis. Function: May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity. Subunit: Interacts with TRAF6. Subcellular Location: Nucleus (Probable). Similarity: Contains 15 C2H2-type zinc fingers. brContains 1 KRAB domain. SWISS: Q8TD23 Gene ID: 171392 Database links: Entrez Gene: 171392 Human SwissProt: Q8TD23 Human Unigene: 264345 Human |
| 1、抗體溶解方法 | |
| 2、抗體修復(fù)方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關(guān)于肽鏈的設(shè)計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
