| 產(chǎn)品編號 | bs-16100R |
| 英文名稱 | FLG2 Rabbit pAb |
| 中文名稱 | FLG2蛋白抗體 |
| 別 名 | FILA2_HUMAN; Filaggrin-2; FLG-2; FLG2; Ifapsoriasin; Intermediate filament-associated and psoriasis-susceptibility protein. |
| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)運(yùn)蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 248 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FLG2: 41-150/2391 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Profilaggrin is a large, insoluble, highly phosphorylated precursor protein and major component of keratohyalin granules in the living cells of the epidermis. During terminal differentiation of the epidermis, profilaggrin is proteolytically processed into active Filaggrin molecules that promote aggregation and disulfide-bond formation of keratin intermediate filaments. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that Filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery. Filaggrin 2, also known as FLG2, Ifapsoriasin or IFPS (intermediate filament-associated and psoriasis-susceptibility protein), is a 2,391 amino acid protein that shares common structural features with Filaggrin. Filaggrin 2 contains ten Filaggrin repeats, two EF-hand domains and belongs to both the S-100 and S100-fused protein families. Similarity: Belongs to the S100-fused protein family. In the N-terminal section; belongs to the S-100 family. Contains 2 EF-hand domains. Contains 10 filaggrin repeats. SWISS: Q5D862 Gene ID: 388698 Database links: Entrez Gene: 388698 Human SwissProt: Q5D862 Human Unigene: 156124 Human |
