| 產(chǎn)品編號(hào) | bs-16028R |
| 英文名稱 | Rabbit Anti-Fascin 2 antibody |
| 中文名稱 | Fascin 2蛋白抗體 |
| 別 名 | Fascin homolog 2, actin bundling protein, retinal Strongylocentrotus purpuratus; Fascin Strongylocentrotus purpuratus homolog 2 actin bundling protein, retinal; Fascin-2; FSCN2; FSCN2_HUMAN; Retinal fascin; RFSN; RP30. |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞骨架 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 55kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Fascin 2: 151-250/492 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Subcellular Location: Cytoplasm > cytoskeleton. Cell projection > stereocilium. Tissue Specificity: Localized specifically in the outer and inner segments of the photoreceptor cells in the retina. DISEASE: Defects in FSCN2 are the cause of retinitis pigmentosa type 30 (RP30) [MIM:607921]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP30 inheritance is autosomal dominant. Similarity: Belongs to the fascin family. SWISS: O14926 Gene ID: 25794 Database links: Entrez Gene: 25794 Human Entrez Gene: 238021 Mouse Omim: 607643 Human SwissProt: O14926 Human SwissProt: Q32M02 Mouse Unigene: 118555 Human Unigene: 375010 Mouse Unigene: 481403 Mouse |
