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C3orf23 Rabbit pAb (bs-15169R)  
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產品編號 bs-15169R
英文名稱 C3orf23 Rabbit pAb
中文名稱 3號染色體開放閱讀框23抗體
別    名 C3orf23; TCAIM_HUMAN; Chromosome 3 open reading frame 23; D9Ertd402e; DKFZp313N0621; FLJ41686; Hypothetical protein LOC285343; MGC119530; MGC119531; MGC119532; MGC119533; TOAG1; Tolerance associated gene 1; Uncharacterized protein C3orf23.  
研究領域 腫瘤  心血管  細胞生物  免疫學  發育生物學  線粒體  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human (predicted: Mouse,Rat,Rabbit)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 58 kDa
檢測分子量
細胞定位 細胞漿 線粒體
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human C3orf23  
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 C3orf23 (chromosome 3 open reading frame 23), also known as FLJ41686, MGC119530, MGC119531, MGC119532, MGC119533 or DKFZp313N062, is a 496 amino acid protein that exists as four alternatively spliced isoforms. C3orf23 is encoded by a gene mapping to human chromosome 3p21.33. Chromosome 3 is made up of approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.

Function:
May regulate T-cell apoptosis (By similarity).

Subcellular Location:
Mitochondrion (By similarity).

SWISS:
Q8N3R3

Gene ID:
285343

Database links:

Entrez Gene: 285343 Human

SwissProt: Q8N3R3 Human

SwissProt: Q66JZ4 Mouse

Unigene: 55131 Human



產品圖片
Paraformaldehyde-fixed, paraffin embedded (human esophagus cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (C3orf23) Polyclonal Antibody, Unconjugated (bs-15169R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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