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Rabbit Anti-Glyt1  antibody (bs-11604R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-11604R
英文名稱 Rabbit Anti-Glyt1  antibody
中文名稱 甘氨酸轉運蛋白1抗體
別    名 SLC6A9; glycine transporter 1; Glyt 1; GlyT-1 antibodyGlyT1; SC6A9_HUMAN; sodium and chloride dependent glycine transporter 1; Sodium- and chloride-dependent glycine transporter 1; Solute carrier family 6 member 9.  
研究領域 細胞生物  神經生物學  轉運蛋白  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse,Rat (predicted: Rabbit,Cow,Dog)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 78kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Glyt1/SLC6A9: 209-285/706 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Na+/Cl- dependent neurotransmitter transporters are a superfamily of transmembrane proteins that contain 12 membrane spanning regions (1). Specifically, the highly hydrophobic Na+/Cl- dependent glycine transporters (GlyT) are crucial for the termination of neurotransmission at glycinergic synapses (2,3). Two different GlyT genes encode GlyT2 and GlyT1, which exists as two isoforms produced by alternative splicing of the same gene located on human chromosome 1p31.3 (3,4). The GlyT1 gene may be an early marker of neural development and encodes glia-specific transporter proteins (3). Although GlyT1 and GlyT2 are both expressed in the brain and spinal cord, each shows a unique pattern of expression (3,5,6). GlyT1 is found only in the white matter of the CNS, whereas GlyT2 is found in the gray matter of the CNS as well as in macrophages and mast cells in peripheral tissues (3,5). The anatomic distribution of GlyT2 mRNA suggests that glycine may act as a supraspinal neurotransmitter and may function as a chemical messenger outside the CNS (5).

Function:
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.

Subcellular Location:
Membrane.

Tissue Specificity:
Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain.

Similarity:
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
SLC6A9 subfamily.

SWISS:
P48067

Gene ID:
6536

Database links:

Entrez Gene: 14664 Mouse

Entrez Gene: 116509 Rat

SwissProt: P28571 Mouse

SwissProt: P28572 Rat

Unigene: 244549 Mouse

Unigene: 32110 Rat



產品圖片
Sample: Cerebrum (Mouse) Lysate at 40 ug Cerebrum(Rat) Lysate at 40 ug Primary: Anti-Glyt1 (bs-11604R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 78 kD Observed band size: 78 kD
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