| 產(chǎn)品編號(hào) | bs-2040R |
| 英文名稱 | Atrial natriuretic factor Rabbit pAb |
| 中文名稱 | 心房鈉尿因子/心鈉素/心房利鈉肽/ANP抗體 |
| 別 名 | Prepronatriodilatin; ANF_HUMAN; Cardiodilatin; ANF; Atrial natriuretic factor; CDD ANF; CDP; PND; Prepronatriodilatin; Nppa; Natriuretic peptides A; Atrial natriuretic peptide; CDD-ANF; ANP. |
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Specific References (3) | bs-2040R has been referenced in 3 publications.
[IF=4.432] Ruomiao Li. et al. Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress. Eur J Pharmacol. 2021 Sep;907:174277 WB ; Rat.
[IF=1.7] Straub, Rainer H., et al. "Increased extracellular water measured by bioimpedance and by increased serum levels of atrial natriuretic peptide in RA patients—signs of volume overload." Clinical Rheumatology (2016): 1-11 IHC-F ; Human.
[IF=0] Malinowski, Nadezhda. Erh?htes extrazellul?res Wasser gemessen durch Bioimpedanz und erh?hter Serumspiegel von atrialem natriuretischen Peptid bei rheumatoider Arthritis–Anzeichen von Volumenüberlastung. Diss. 2015. IHC-F ; Human.
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| 研究領(lǐng)域 | 心血管 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 激酶和磷酸酶 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat (predicted: Rabbit,Pig,Sheep,Cow,Dog,GuineaPig,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 3/17 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ANP: 124-151/153 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]. Function: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Subunit: Interacts with NPR1. Subcellular Location: Secreted. Post-translational modifications: Cleaved by CORIN upon secretion to produce the functional hormone. DISEASE: Atrial fibrillation, familial, 6 (ATFB6) [MIM:612201]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the natriuretic peptide family. SWISS: P01160 Gene ID: 4878 Database links: Entrez Gene: 4878 Human Entrez Gene: 230899 Mouse Omim: 108780 Human SwissProt: P01160 Human SwissProt: P05125 Mouse Unigene: 75640 Human 心鈉素（心房利尿鈉肽）：心鈉素主要是由心房分泌的一種含有28個(gè)氨基酸并由二硫鍵結(jié)合的一環(huán)形肽分子，具有強(qiáng)大的利鈉、利尿、擴(kuò)血管等作用。使血管舒張，外周阻力降低；使每博輸出量變少，心率減慢；腎排水排鈉增多；導(dǎo)致體內(nèi)細(xì)胞外液量減少。 心鈉素主要來(lái)源于心肌纖維，但腦、腎、肺、腎上腺等器官、組織也能表達(dá)，但產(chǎn)生及分泌的方式有一定差異。 |
| 產(chǎn)品圖片 |
Sample:
Heart (Mouse) Lysate at 40 ug
Heart (Rat) Lysate at 40 ug
Primary: Anti-Atrial natriuretic factor (bs-2040R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 3/17 kD
Observed band size: 15 kD
Paraformaldehyde-fixed, paraffin embedded (Rat heart); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Atrial natriuretic factor) Polyclonal Antibody, Unconjugated (bs-2040R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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