| 產(chǎn)品編號 | bs-0622R |
| 英文名稱 | Gamma Synuclein Rabbit pAb |
| 中文名稱 | 核突觸蛋白-γ抗體 |
| 別 名 | BCSG1; gamma-Synuclein; Breast cancer specific gene 1 protein; Breast cancer specific protein 1; Breast cancer-specific gene 1 protein; gamma synuclein; Persyn; PRSN; SNCG; SR; Synoretin; Synuclein gamma; SYUG_HUMAN. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) Alzheimer's |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 13.5 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human gamma Synuclein: 2-123/123 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The synculein family consists of 3 highly conserved proteins of between 120 and 140 amino acids that share substantial sequence homology. Each has a series of loosely repeated motifs throughout the first 93 amino acids and an acid region toward the C terminal. The proteins are heat stable and relatively soluble. Three synucleins have been identified and termed alpha, beta and gamma synuclein and are located in the neuronal cytosol and enriched in presynaptic terminals,gamma synuclein is also expressed in many other non-neuronal tissues. Although the precise function of the synucleins are unknown a role in membrane plasticity has been suggested. The synucleins have been implicated in a number of diseases. It has been reported that in breast cancer increased expression of gamma synuclein correlates with disease progression. Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. Subunit: May be a centrosome-associated protein. Subcellular Location: Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. Tissue Specificity: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. Post-translational modifications: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. Similarity: Belongs to the synuclein family. SWISS: O76070 Gene ID: 6623 Database links: Entrez Gene: 6623 Human Entrez Gene: 20618 Mouse Omim: 602998 Human SwissProt: O76070 Human SwissProt: Q9Z0F7 Mouse Unigene: 349470 Human Unigene: 282800 Mouse Unigene: 2883 Rat 神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology） SNCG（gamma-Synuclein）蛋白在各種癌癥組織中呈廣范表達(dá)，存在較高的異常表達(dá)率，SNCG蛋白表達(dá)與癌癥分期有關(guān)，I期表達(dá)率低，Ⅱ～Ⅳ期表達(dá)率高。尤其重要的是：經(jīng)研究發(fā)現(xiàn)無論何種原發(fā)性腫瘤，SNCG蛋白的出現(xiàn)與癌癥遠(yuǎn)處轉(zhuǎn)移都有很高的關(guān)聯(lián)性。 |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SYUG) Polyclonal Antibody, Unconjugated (bs-0622R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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